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Building sealants play a critical role in protecting structures from moisture intrusion and maintaining airtightness by filling joints and gaps in exterior building components. As modern construction increasingly utilizes durable materials such as ceramic-based siding boards and other advanced cladding systems, the demand for sealants with enhanced weather resistance, flexibility, and long-term durability has grown significantly. At the same time, increasingly stringent performance requirements, including long-term resistance to joint movement, staining, and environmental degradation, have exposed limitations in conventional non-reactive plasticizers commonly used to improve sealant workability and flexibility. Excessive use of these plasticizers can lead to bleeding, surface contamination, and deterioration of mechanical properties over time. To address these challenges, Toagosei developed the US Series of reactive plasticizers, acrylic oligomers containing alkoxysilyl functional groups capable of co-crosslinking with moisture-curable sealant resins. This paper examines the design, properties, and performance of these reactive plasticizers, highlighting their ability to improve flexibility, weather resistance, bleed resistance, and mechanical-property control in sealant and adhesive applications.